Andrea Čongrádyová


Transition metals play an important role in medicinal biochemistry as drugs to treat several human diseases. Recently an extensive research for development of new copper-based drugs usable as pharmaceuticals with antitumoral, antimicrobial or antifungal properties has been stimulated in many laboratories. The properties of copper-coordinated compounds, whether in classical inorganic coordination complexes, in organometallic compounds, or in bioinorganic model compounds are largely determined by the nature of ligands and donor atoms bound to the metal ion. This review will cover the developments in the chemistry of copper complexes with phenanthroline ligand or its derivates. The attention of inorganic biochemistry has been focused on the coordination and intercalating or DNA cleaving properties as well as on analytical applications of copper complexes with phenanthroline-based ligands which can be featured by an interacting with DNA inducing DNA-cleavage.

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